Estimating Toxic Potency of Paraquat in Human Poisoning: A Systematic Review and Meta-Analysis

Funding agency: World Health Organization Objective The objective is to accurately estimate the real-world toxic potency of Paraquat in humans by synthesizing evidence on case fatality rates, clinical severity scores, and other toxicity indicators. The findings aim to refine hazard classifications that currently rely mainly on animal LD₅₀ data. Methodology [...]

Optimal HbA1c Target value for Minimizing Diabetes Complications Amongst Adult Type 1 Diabetes Mellitus Patients: Systematic Review and Meta-Analysis

Funding agency: World Health Organization Objective The project aims to determine the ideal HbA1c target value required to minimize long-term microvascular and macrovascular complications in adults with Type 1 Diabetes Mellitus. It seeks to identify the threshold that best reduces risks such as diabetic retinopathy, nephropathy, and cardiovascular disease. Methodology [...]

Optimal Frequency of HbA1c Monitoring for Effective Glycaemic Control and Prevention of Complications Amongst Adult Type 1 Diabetes Mellitus Patients: A Systematic Review and Meta-Analysis

Funding agency: World Health Organization) Objective The objective of this project is to rigorously synthesize evidence on how different HbA1c testing frequencies affect glycaemic control and long-term complications in adults with Type 1 Diabetes Mellitus. The review aims to determine the most effective monitoring schedule to support improved clinical outcomes. [...]

Systematic collection and evaluation of PFAS occurrence data in the water cycle to better understand PFAS occurrence in drinking-water

Funding Agency: World Health Organization (WHO) under the Water, Sanitation, Hygiene and Health Unit within the Environment, Climate Change, One Health, and Migration Department Objective The objective of this project is to evaluate the occurrence of PFAS throughout the water cycle to better understand their presence in drinking water. This [...]

Systematic Evidence Collection and Quality Assessment supporting the risk assessment of chronic cancer and noncancer toxicity values for PFAS

Funding agency: World Health Organization (WHO). Objective The objective of this project is to assess the health impacts of ingested PFAS, especially those present in drinking water, by applying and refining methodologies developed in Phase 1. It further seeks to generate high-quality evidence to support the development of WHO health-based [...]